GUCY1A1

Across TCGA patient cohorts, GUCY1A1 mutation is significantly associated with the RNA expression of many other genes, with 5,660 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUCY1A1-associated genes across cancer lineages are MIPEPP2, GMNN, and CENPA. Each is linked with GUCY1A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GUCY1A1-to-partner and partner-to-GUCY1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIPEPP2 grouped by GUCY1A1-low versus GUCY1A1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY1A1→partner) and Y-score (partner→GUCY1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIPEPP2 →	+0.034	+5.276	<.001	.001	3	4
UCEC	GMNN →	+0.606	+1.928	<.001	<.001	3	4
LUSC	CENPA →	+0.593	+3.596	.009	.001	3	4
UCEC	UBE2T →	+0.626	+1.949	<.001	<.001	3	4
READ	RNU4-65P →	+0.220	+4.257	<.001	.007	3	3
UCEC	ZBED4 →	+0.387	+2.098	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,660 associations by consensus.

MIPEPP2 by GUCY1A1 expression — READ

Explore this box plot interactively →