GUCY1A1

Across TCGA patient cohorts, GUCY1A1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUCY1A1-associated genes across cancer lineages are AR, TFRC, and CD49b. Each is linked with GUCY1A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GUCY1A1-to-partner and partner-to-GUCY1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AR grouped by GUCY1A1-low versus GUCY1A1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY1A1→partner) and Y-score (partner→GUCY1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	AR →	+0.351	+2.321	.004	.033	3	3
COAD	TFRC →	+0.493	+2.841	.040	.033	3	3
BLCA	CD49b →	-0.375	-2.321	.009	.033	3	2
COAD	PDCD4 →	-0.537	-2.313	.004	.035	3	2
COAD	PKC-b-II_pS660 →	-0.418	-3.169	.009	.018	3	2
SKCM	p27 →	-0.132	-1.700	.030	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

AR by GUCY1A1 expression — BLCA

Explore this box plot interactively →