GUCD1

Across TCGA cell cohorts, GUCD1 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GUCD1-associated genes across cancer lineages are CFHR2, SLC32A1, and ITIH6. Each is linked with GUCD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GUCD1-to-partner and partner-to-GUCD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by GUCD1-low versus GUCD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCD1→partner) and Y-score (partner→GUCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CFHR2 →	+0.057	+5.022	<.001	.002	3	1
BLOOD_Leukemia	SLC32A1 →	+0.809	+4.223	<.001	.001	3	1
BLOOD_Leukemia	ITIH6 →	+0.019	+3.754	<.001	.006	3	1
BLOOD_Leukemia	FGF14 →	+0.336	+3.656	.004	.006	3	1
BLOOD_Leukemia	PAX1 →	+0.034	+3.475	<.001	.006	3	1
BLOOD_Leukemia	BRDT →	+0.136	+3.342	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

CFHR2 by GUCD1 expression — LARGE_INTESTINE

Explore this box plot interactively →