Across TCGA pan-cancer cohorts, GUCA2A mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of GUCA2A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GUCA2A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types GUCA2A is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

COAD are the cancer types where GUCA2A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GUCA2A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−1.897	<.001	11	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: GUCA2A RNA expression & survival · all GUCA2A data types