GUCA1C

Across TCGA pan-cancer cohorts, GUCA1C Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GUCA1C data layer compared with 17 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher GUCA1C Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GUCA1C expression acts as an unfavorable survival marker.

LUSC, LUAD, and SKCM are the cancer types where GUCA1C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	III,IV	0.235	0.638	.041	3	view →
LUAD	OS	Median	II,III,IV	0.250	0.709	.049	3	view →
SKCM	OS	Median	All	0.709	0.875	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GUCA1C–LUSC (DFS)

Open the LUSC breakdown →