GUCA1A

Across TCGA pan-cancer cohorts, GUCA1A Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GUCA1A data layer compared with 24 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GUCA1A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GUCA1A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, BLCA, and UCEC are the cancer types where GUCA1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.192	0.667	<.001	44	view →
BLCA	OS	Median	III,IV	0.141	0.581	.011	12	view →
UCEC	DFS	Median	II,III,IV	1.000	0.487	.041	8	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GUCA1A–LUAD (DFS)

Open the LUAD breakdown →