GUCA1A

Across TCGA cell cohorts, GUCA1A RNA expression is significantly associated with the go_rna of many other GO terms, with 486 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GUCA1A-associated GO terms across cancer lineages are Positive regulation of proteasomal ubiquitin-dependent protein catabolic process, Negative regulation of intracellular steroid hormone receptor signaling pathway, and Fusion of sperm to egg plasma membrane involved in single fertilization. Each is linked with GUCA1A in more than 3 cancer types. Because this analysis shows association rather than direction, both GUCA1A-to-partner and partner-to-GUCA1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of proteasomal ubiquitin-dependent protein catabolic process grouped by GUCA1A-low versus GUCA1A-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCA1A→partner) and Y-score (partner→GUCA1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.073	+0.034	<.001	.006	3	4
LARGE_INTESTINE	Negative regulation of intracellular steroid hormone receptor signaling pathway →	+0.042	+0.027	.007	.001	3	3
LUNG_NSCLC_LUAD	Fusion of sperm to egg plasma membrane involved in single fertilization →	-0.167	-0.022	.003	.002	2	4
UPPER_AERODIGESTIVE_TRACT	Positive regulation of autophagy →	+0.063	+0.035	<.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	Peptidyl-serine phosphorylation →	+0.060	+0.039	<.001	.005	3	3
UPPER_AERODIGESTIVE_TRACT	Peptidyl-serine modification →	+0.062	+0.040	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 486 associations by consensus.

Positive regulation of proteasomal ubiquitin-dependent protein catabolic process by GUCA1A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →