GTSF1

Across TCGA pan-cancer cohorts, GTSF1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GTSF1 data layer compared with 17 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GTSF1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GTSF1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where GTSF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.562	0.883	.007	34	view →
LUAD	DFS	Tertile	All	1.000	0.562	.004	17	view →
PDAC	DFS	Median	III,IV	0.680	0.206	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GTSF1–HNSC (OS)

Open the HNSC breakdown →