GTSE1

Across TCGA pan-cancer cohorts, GTSE1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GTSE1 data layer compared with 26 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher GTSE1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GTSE1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

SCLC, UCEC, and COAD are the cancer types where GTSE1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	II,III,IV	0.137	0.700	<.001	48	view →
UCEC	DFS	Median	All	0.962	0.618	.014	20	view →
COAD	OS	Median	III,IV	0.159	0.692	.021	12	view →
BLCA	DFS	Median	III,IV	0.196	0.576	.006	12	view →
LUAD	OS	Median	III,IV	0.147	0.679	.001	12	view →
LUSC	DFS	Median	All	1.000	0.363	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GTSE1–SCLC (OS)

Open the SCLC breakdown →