GTSE1

Across TCGA patient cohorts, GTSE1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTSE1-associated genes across cancer lineages are Caspase-7-cleavedD198, C-Raf, and NF2. Each is linked with GTSE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GTSE1-to-partner and partner-to-GTSE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by GTSE1-low versus GTSE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTSE1→partner) and Y-score (partner→GTSE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.583	+3.459	.007	.005	3	3
UCEC	C-Raf →	+0.140	+1.847	.008	.008	3	3
UCEC	NF2 →	+0.234	+1.874	.003	.049	3	2
UCEC	PCNA →	+0.229	+2.247	.003	.001	3	2
UCEC	Rictor_pT1135 →	-0.115	-2.321	.002	.005	3	2
UCEC	TFRC →	+0.549	+2.700	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Caspase-7-cleavedD198 by GTSE1 expression — UCEC

Explore this box plot interactively →