GTPBP8

Across TCGA pan-cancer cohorts, GTPBP8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GTPBP8 data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GTPBP8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GTPBP8 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, UCEC, and HNSC are the cancer types where GTPBP8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.850	0.503	.007	40	view →
UCEC	DFS	Median	III,IV	1.000	0.280	.007	24	view →
HNSC	OS	Median	All	1.000	0.947	.019	11	view →
PDAC	DFS	Tertile	III,IV	0.277	0.903	.024	6	view →
LSCC	DFS	Tertile	III,IV	0.984	0.596	.032	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GTPBP8–CCRCC (DFS)

Open the CCRCC breakdown →