GTPBP8

Across TCGA cell cohorts, GTPBP8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,858 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GTPBP8-associated GO terms across cancer lineages are Sister chromatid cohesion, Mitotic sister chromatid cohesion, and Positive regulation of mRNA processing. Each is linked with GTPBP8 in more than 14 cancer types. Because this analysis shows association rather than direction, both GTPBP8-to-partner and partner-to-GTPBP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sister chromatid cohesion grouped by GTPBP8-low versus GTPBP8-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GTPBP8→partner) and Y-score (partner→GTPBP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Sister chromatid cohesion →	+0.097	+1.050	<.001	<.001	3	15
BLOOD_Lymphoma	Mitotic sister chromatid cohesion →	+0.100	+0.839	<.001	<.001	3	14
BLOOD_Myeloma	Positive regulation of mRNA processing →	+0.113	+0.858	.006	.001	3	14
PANCREAS	tRNA wobble guanine modification →	+0.120	+0.877	<.001	<.001	3	14
BREAST	Chromosome segregation →	+0.104	+1.079	<.001	<.001	3	13
BLOOD_Myeloma	Double-strand break repair →	+0.058	+0.789	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,858 associations by consensus.

Sister chromatid cohesion by GTPBP8 expression — BREAST

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