GTPBP4

Across TCGA pan-cancer cohorts, GTPBP4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GTPBP4 data layer compared with 22 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GTPBP4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GTPBP4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, CCRCC, and HNSC are the cancer types where GTPBP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.919	0.361	.007	28	view →
CCRCC	DFS	Tertile	III,IV	0.367	0.757	.002	25	view →
HNSC	DFS	Quartile	III,IV	0.623	0.924	.008	17	view →
LSCC	DFS	Quartile	II,III,IV	0.926	0.555	.016	9	view →
GBM	OS	Tertile	All	0.776	0.375	.002	6	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GTPBP4–UCEC (DFS)

Open the UCEC breakdown →