GTPBP4

Across TCGA cell cohorts, GTPBP4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GTPBP4-associated genes across cancer lineages are PAX4, C9orf92, and MMP26. Each is linked with GTPBP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTPBP4-to-partner and partner-to-GTPBP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAX4 grouped by GTPBP4-low versus GTPBP4-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTPBP4→partner) and Y-score (partner→GTPBP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PAX4 →	+0.006	+5.000	<.001	.005	3	1
BLOOD_Leukemia	C9orf92 →	+0.109	+5.539	<.001	.003	3	1
LARGE_INTESTINE	MMP26 →	+0.052	+4.217	<.001	.001	3	1
LARGE_INTESTINE	OR10K1 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	ECSCR →	+0.093	+3.777	.009	.007	3	1
LUNG_NSCLC_LUSC	OLIG3 →	+0.071	+3.832	.002	.008	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PAX4 by GTPBP4 expression — KIDNEY

Explore this box plot interactively →