GTPBP2

Across TCGA patient cohorts, GTPBP2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTPBP2-associated genes across cancer lineages are eIF4E, MSH2, and Di-Ras3. Each is linked with GTPBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTPBP2-to-partner and partner-to-GTPBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by GTPBP2-low versus GTPBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTPBP2→partner) and Y-score (partner→GTPBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.169	+2.013	.020	.016	3	2
UCEC	MSH2 →	-0.256	-1.674	.001	.040	3	2
UCEC	Di-Ras3 →	-0.131	-2.308	.010	.033	3	2
UCEC	JNK2 →	+0.267	+2.459	<.001	<.001	3	1
UCEC	Ku80 →	+0.263	+1.750	.001	.004	3	1
UCEC	MEK1 →	+0.402	+3.700	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

eIF4E by GTPBP2 expression — UCEC

Explore this box plot interactively →