GTPBP2

Across TCGA cell cohorts, GTPBP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,756 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GTPBP2-associated GO terms across cancer lineages are Macroautophagy, Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, and Negative regulation of transcription initiation by RNA polymerase II. Each is linked with GTPBP2 in more than 12 cancer types. Because this analysis shows association rather than direction, both GTPBP2-to-partner and partner-to-GTPBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macroautophagy grouped by GTPBP2-low versus GTPBP2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GTPBP2→partner) and Y-score (partner→GTPBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.060	+1.026	<.001	<.001	3	13
STOMACH	Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.117	+1.005	<.001	.002	3	12
BREAST	Negative regulation of transcription initiation by RNA polymerase II →	+0.096	+0.617	.001	.002	3	12
BREAST	Negative regulation of DNA-templated transcription initiation →	+0.096	+0.617	.001	.002	3	12
STOMACH	Process utilizing autophagic mechanism →	+0.062	+1.006	<.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Post-Golgi vesicle-mediated transport →	+0.070	+1.121	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,756 associations by consensus.

Macroautophagy by GTPBP2 expression — UPPER_AERODIGESTIVE_TRACT

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