GTPBP10

Across TCGA patient cohorts, GTPBP10 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTPBP10-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and PCNA. Each is linked with GTPBP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTPBP10-to-partner and partner-to-GTPBP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GTPBP10-low versus GTPBP10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTPBP10→partner) and Y-score (partner→GTPBP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.212	-2.321	.040	.006	3	1
UCEC	FoxM1 →	+0.241	+3.000	.023	.001	3	1
UCEC	PCNA →	+0.255	+2.321	.004	.006	3	1
UCEC	PDCD4 →	-0.805	-3.690	<.001	.001	3	1
UCEC	Annexin-1 →	+0.543	+3.341	.012	.005	3	1
UCEC	S6_pS240_S244 →	+0.348	+1.807	.038	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by GTPBP10 expression — UCEC

Explore this box plot interactively →