GTF3C6

Across TCGA pan-cancer cohorts, GTF3C6 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated GTF3C6 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher GTF3C6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GTF3C6 expression acts as an unfavorable survival marker, although some lineages such as THCA and LUSC show a favorable association.

LIHC, LUAD, and KICH are the cancer types where GTF3C6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.464	0.617	<.001	102	view →
LUAD	OS	Median	All	0.611	0.754	<.001	84	view →
KICH	OS	Tertile	II,III,IV	0.562	1.000	.002	57	view →
ACC	OS	Quartile	II,III,IV	0.673	0.963	<.001	49	view →
SCLC	OS	Median	IV	0.219	0.729	.003	40	view →
UVM	OS	Median	III,IV	0.289	1.000	.005	35	view →
THCA	OS	Median	III,IV	0.988	0.906	.015	33	view →
HNSC	DFS	Quartile	IV	0.533	0.713	.008	20	view →
SKCM	DFS	Median	II,III,IV	0.477	0.683	.003	16	view →
STAD	OS	Tertile	IV	0.117	0.620	.018	15	view →
LUSC	OS	Quartile	II,III,IV	0.906	0.620	.013	15	view →
KIRC	DFS	Median	III,IV	0.586	0.358	.001	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GTF3C6–LIHC (DFS)

Open the LIHC breakdown →