GTF3C5

Across TCGA pan-cancer cohorts, GTF3C5 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GTF3C5 data layer compared with 28 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher GTF3C5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GTF3C5 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, UCEC, and KICH are the cancer types where GTF3C5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	IV	0.095	0.592	.004	16	view →
UCEC	DFS	Median	II,III,IV	0.933	0.436	.019	14	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
HNSC	DFS	Median	All	0.173	0.626	.023	12	view →
PRAD	DFS	Median	All	0.187	0.775	.008	6	view →
SKCM	OS	Median	III,IV	0.132	0.393	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GTF3C5–CESC (OS)

Open the CESC breakdown →