GTF3C5

Across TCGA pan-cancer cohorts, GTF3C5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GTF3C5 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GTF3C5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GTF3C5 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, PDAC, and GBM are the cancer types where GTF3C5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.929	0.550	<.001	17	view →
PDAC	DFS	Quartile	All	0.593	0.909	.005	15	view →
GBM	OS	Median	All	0.585	0.246	.008	5	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.867	.008	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GTF3C5–LSCC (OS)

Open the LSCC breakdown →