GTF3C5

Across TCGA patient cohorts, GTF3C5 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF3C5-associated genes across cancer lineages are MSH2, p27_pT198, and PDCD4. Each is linked with GTF3C5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF3C5-to-partner and partner-to-GTF3C5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by GTF3C5-low versus GTF3C5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF3C5→partner) and Y-score (partner→GTF3C5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.200	-2.295	.020	.033	3	2
UCEC	p27_pT198 →	+0.089	+2.321	.025	.034	3	2
UCEC	PDCD4 →	-0.415	-1.765	.018	.014	3	2
UCEC	Caspase-7-cleavedD198 →	+0.527	+2.019	.017	.017	3	2
UCEC	14-3-3_beta →	-0.089	-3.295	.018	.009	3	1
UCEC	EGFR_pY1068 →	-0.251	-1.700	.007	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

MSH2 by GTF3C5 expression — UCEC

Explore this box plot interactively →