GTF3C5

Across TCGA cell cohorts, GTF3C5 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GTF3C5-associated genes across cancer lineages are CCDC105, OR10G7, and LCE1F. Each is linked with GTF3C5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF3C5-to-partner and partner-to-GTF3C5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC105 grouped by GTF3C5-low versus GTF3C5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF3C5→partner) and Y-score (partner→GTF3C5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CCDC105 →	+0.004	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR10G7 →	+0.012	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	LCE1F →	+0.113	+4.662	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP21-2 →	+0.146	+5.209	<.001	.005	3	1
BREAST	IZUMO3 →	+0.039	+5.169	<.001	.005	3	1
OVARY	IFNW1 →	+0.052	+4.029	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CCDC105 by GTF3C5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →