GTF3C4

Across TCGA patient cohorts, GTF3C4 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF3C4-associated genes across cancer lineages are FASN, JNK_pT183_Y185, and Caspase-7-cleavedD198. Each is linked with GTF3C4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF3C4-to-partner and partner-to-GTF3C4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by GTF3C4-low versus GTF3C4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF3C4→partner) and Y-score (partner→GTF3C4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.294	+1.502	.042	.030	3	2
UCEC	JNK_pT183_Y185 →	-0.176	-2.115	.004	.017	3	2
UCEC	Caspase-7-cleavedD198 →	+0.620	+2.135	.004	.010	3	2
UCEC	EGFR_pY1068 →	-0.270	-1.906	.003	.015	3	1
UCEC	eIF4E →	+0.189	+3.183	.014	.009	3	1
UCEC	FoxM1 →	+0.251	+1.847	.008	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

FASN by GTF3C4 expression — UCEC

Explore this box plot interactively →