GTF3C4

Across TCGA cell cohorts, GTF3C4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible GTF3C4-associated genes across cancer lineages are CALHM4, SPEM3, and OR12D3. Each is linked with GTF3C4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF3C4-to-partner and partner-to-GTF3C4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CALHM4 grouped by GTF3C4-low versus GTF3C4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF3C4→partner) and Y-score (partner→GTF3C4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CALHM4 →	+0.038	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	SPEM3 →	+0.013	+4.409	<.001	.005	3	1
OVARY	OR12D3 →	+0.016	+5.807	<.001	.001	3	1
OVARY	DEFA6 →	+0.111	+5.196	.004	.005	3	1
BLOOD_Lymphoma	OR8D2 →	+0.074	+4.867	<.001	.009	3	1
LARGE_INTESTINE	RSC1A1 →	+0.819	+3.519	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CALHM4 by GTF3C4 expression — BLOOD_Leukemia

Explore this box plot interactively →