GTF3C3

Across TCGA pan-cancer cohorts, GTF3C3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GTF3C3 data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher GTF3C3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GTF3C3 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

GBM, LSCC, and PDAC are the cancer types where GTF3C3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.531	0.264	.003	16	view →
LSCC	DFS	Tertile	II,III,IV	0.892	0.455	.003	15	view →
PDAC	DFS	Tertile	All	0.683	0.828	.008	13	view →
COAD	DFS	Median	All	1.000	0.904	.042	12	view →
HNSC	DFS	Tertile	All	0.990	0.898	.027	5	view →
LUAD	DFS	Tertile	II,III,IV	0.518	0.841	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GTF3C3–GBM (DFS)

Open the GBM breakdown →