GTF3C3

Across TCGA patient cohorts, GTF3C3 mutation is significantly associated with the RNA expression of many other genes, with 2,293 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF3C3-associated genes across cancer lineages are TAF9, TTC19, and EIF2S1. Each is linked with GTF3C3 in more than 3 cancer types. Because this analysis shows association rather than direction, both GTF3C3-to-partner and partner-to-GTF3C3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAF9 grouped by GTF3C3-low versus GTF3C3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF3C3→partner) and Y-score (partner→GTF3C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TAF9 →	+0.620	+2.321	<.001	<.001	3	4
STAD	TTC19 →	+0.531	+3.195	.002	.009	3	4
UCEC	EIF2S1 →	+0.455	+2.595	<.001	<.001	3	4
UCEC	NUSAP1 →	+0.527	+1.807	.005	<.001	3	4
UCEC	CCNB2 →	+0.495	+2.279	.005	<.001	3	3
UCEC	CHCHD4 →	+0.287	+1.538	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,293 associations by consensus.

TAF9 by GTF3C3 expression — UCEC

Explore this box plot interactively →