GTF3C3

Across TCGA patient cohorts, GTF3C3 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF3C3-associated genes across cancer lineages are eIF4E, ACC1, and Rictor_pT1135. Each is linked with GTF3C3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF3C3-to-partner and partner-to-GTF3C3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by GTF3C3-low versus GTF3C3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF3C3→partner) and Y-score (partner→GTF3C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.145	+2.169	.034	.003	3	2
UCEC	ACC1 →	+0.264	+2.713	.025	.003	3	2
UCEC	Rictor_pT1135 →	-0.084	-1.459	.011	.012	3	2
UCEC	ATM →	-0.394	-1.716	.007	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.419	+1.697	.029	.012	3	2
STAD	NF2 →	+0.168	+3.000	.020	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

eIF4E by GTF3C3 expression — UCEC

Explore this box plot interactively →