GTF3C3

Across TCGA cell cohorts, GTF3C3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,180 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GTF3C3-associated GO terms across cancer lineages are 5S class rRNA transcription by RNA polymerase III, Nucleocytoplasmic transport, and Centrosome cycle. Each is linked with GTF3C3 in more than 18 cancer types. Because this analysis shows association rather than direction, both GTF3C3-to-partner and partner-to-GTF3C3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 5S class rRNA transcription by RNA polymerase III grouped by GTF3C3-low versus GTF3C3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF3C3→partner) and Y-score (partner→GTF3C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	5S class rRNA transcription by RNA polymerase III →	+0.178	+0.895	<.001	<.001	3	19
BLOOD_Lymphoma	Nucleocytoplasmic transport →	+0.074	+1.060	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.106	+1.051	<.001	<.001	3	17
BLOOD_Lymphoma	Nuclear transport →	+0.074	+1.080	<.001	<.001	3	17
BONE	Microtubule nucleation →	+0.150	+0.803	<.001	.003	3	17
UPPER_AERODIGESTIVE_TRACT	DNA biosynthetic process →	+0.060	+0.811	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,180 associations by consensus.

5S class rRNA transcription by RNA polymerase III by GTF3C3 expression — BONE

Explore this box plot interactively →