GTF3C3

Across TCGA cell cohorts, GTF3C3 mutation is significantly associated with the RNA expression of many other genes, with 83 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GTF3C3-associated genes across cancer lineages are RCVRN, MC2R, and MAGEB16. Each is linked with GTF3C3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF3C3-to-partner and partner-to-GTF3C3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RCVRN grouped by GTF3C3-low versus GTF3C3-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF3C3→partner) and Y-score (partner→GTF3C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RCVRN →	+0.089	+4.044	<.001	.003	3	1
STOMACH	MC2R →	+0.005	+3.794	<.001	.003	3	1
STOMACH	MAGEB16 →	+0.744	+4.044	<.001	.003	3	1
STOMACH	SPANXD →	+0.919	+4.280	<.001	.001	3	1
STOMACH	USP17L4 →	+0.029	+3.632	.005	.009	3	1
LARGE_INTESTINE	VAPA →	+0.558	+3.212	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

RCVRN by GTF3C3 expression — STOMACH

Explore this box plot interactively →