GTF3C2

Across TCGA pan-cancer cohorts, GTF3C2 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GTF3C2 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GTF3C2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GTF3C2 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

COAD, SKCM, and LUSC are the cancer types where GTF3C2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.028	0.649	<.001	9	view →
SKCM	DFS	Median	II,III,IV	1.000	0.680	.015	9	view →
LUSC	OS	Median	II,III,IV	0.157	0.406	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GTF3C2–COAD (DFS)

Open the COAD breakdown →