GTF3C2

Across TCGA patient cohorts, GTF3C2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF3C2-associated genes across cancer lineages are MIG-6, Tuberin_pT1462, and ASNS. Each is linked with GTF3C2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF3C2-to-partner and partner-to-GTF3C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by GTF3C2-low versus GTF3C2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF3C2→partner) and Y-score (partner→GTF3C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIG-6 →	+0.103	+2.229	.026	.032	3	2
UCEC	Tuberin_pT1462 →	+0.254	+1.807	.001	.004	3	2
COAD	ASNS →	+0.548	+2.178	.003	.035	3	2
UCEC	ATM →	-0.657	-2.986	<.001	<.001	3	2
UCEC	eEF2 →	+0.302	+1.700	.013	.040	3	2
UCEC	Akt_pT308 →	+0.439	+1.247	.041	.045	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

MIG-6 by GTF3C2 expression — COAD

Explore this box plot interactively →