GTF3C2

Across TCGA cell cohorts, GTF3C2 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GTF3C2-associated genes across cancer lineages are TEX48, ODF1, and ETNPPL. Each is linked with GTF3C2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF3C2-to-partner and partner-to-GTF3C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX48 grouped by GTF3C2-low versus GTF3C2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF3C2→partner) and Y-score (partner→GTF3C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TEX48 →	+0.037	+4.060	<.001	.003	3	2
SKIN	ODF1 →	+0.026	+6.022	<.001	.001	3	1
LARGE_INTESTINE	ETNPPL →	+0.211	+3.758	.003	.004	3	1
LARGE_INTESTINE	SSMEM1 →	+0.025	+3.766	.001	.004	3	1
LARGE_INTESTINE	HTR1E →	+0.070	+3.345	<.001	.007	3	1
LARGE_INTESTINE	OLIG1 →	+0.168	+3.453	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

TEX48 by GTF3C2 expression — BLOOD_Leukemia

Explore this box plot interactively →