GTF3C1

Across TCGA pan-cancer cohorts, GTF3C1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GTF3C1 data layer compared with 22 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GTF3C1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GTF3C1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, PDAC, and GBM are the cancer types where GTF3C1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.927	0.563	<.001	22	view →
PDAC	OS	Tertile	All	0.277	0.456	.011	9	view →
GBM	OS	Quartile	All	0.576	0.282	.011	9	view →
LUAD	DFS	Median	III,IV	0.699	0.341	.003	7	view →
HNSC	OS	Median	All	0.800	0.888	.016	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GTF3C1–LSCC (OS)

Open the LSCC breakdown →