GTF3C1

Across TCGA patient cohorts, GTF3C1 mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF3C1-associated genes across cancer lineages are INPP4B, MEK1, and c-Kit. Each is linked with GTF3C1 in more than 4 cancer types. Because this analysis shows association rather than direction, both GTF3C1-to-partner and partner-to-GTF3C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by GTF3C1-low versus GTF3C1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF3C1→partner) and Y-score (partner→GTF3C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.568	-3.807	<.001	<.001	3	5
UCEC	MEK1 →	+0.264	+1.447	.004	.002	3	4
SKCM	c-Kit →	-0.523	-1.459	.013	.011	3	4
STAD	Cyclin-B1 →	+0.598	+3.169	.004	.018	2	5
COAD	GAPDH →	+0.501	+3.000	.007	.034	3	3
STAD	4E-BP1 →	+0.421	+3.000	.001	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

INPP4B by GTF3C1 expression — COAD

Explore this box plot interactively →