GTF3C1

Across TCGA cell cohorts, GTF3C1 mutation is significantly associated with the RNA expression of many other genes, with 2,048 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GTF3C1-associated genes across cancer lineages are LYG1, GRSF1, and ACAD8. Each is linked with GTF3C1 in more than 4 cancer types. Because this analysis shows association rather than direction, both GTF3C1-to-partner and partner-to-GTF3C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYG1 grouped by GTF3C1-low versus GTF3C1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF3C1→partner) and Y-score (partner→GTF3C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LYG1 →	+0.963	+2.850	<.001	<.001	3	5
BLOOD_Leukemia	GRSF1 →	+0.665	+3.730	<.001	<.001	3	3
BLOOD_Leukemia	ACAD8 →	+0.754	+2.674	<.001	.003	3	3
BLOOD_Leukemia	ZBTB49 →	+0.500	+2.614	<.001	.003	3	3
BLOOD_Leukemia	SNTG2 →	+0.896	+2.584	<.001	.002	3	3
BLOOD_Leukemia	CRLF3 →	+0.539	+3.415	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,048 associations by consensus.

LYG1 by GTF3C1 expression — LARGE_INTESTINE

Explore this box plot interactively →