GTF2IRD2P1

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, GTF2IRD2P1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2IRD2P1-associated genes across cancer lineages are Akt_pS473, JNK_pT183_Y185, and Notch1. Each is linked with GTF2IRD2P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2IRD2P1-to-partner and partner-to-GTF2IRD2P1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2IRD2P1→partner) and Y-score (partner→GTF2IRD2P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SKCMAkt_pS473 →+0.574+1.754.004.04732
UCECJNK_pT183_Y185 →-0.124-1.209.023.03532
UCECNotch1 →+0.181+2.000<.001<.00132
UCECS6_pS240_S244 →+0.400+2.502.002.00132
UCECXBP1 →-0.154-1.986<.001.00832
UCECASNS →+0.368+1.662.001.01032
Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Exploration