GTF2IRD2B

Across TCGA patient cohorts, GTF2IRD2B mutation is significantly associated with the RNA expression of many other genes, with 663 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2IRD2B-associated genes across cancer lineages are TRBV22OR9-2, LINC00845, and CWC25. Each is linked with GTF2IRD2B in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2IRD2B-to-partner and partner-to-GTF2IRD2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRBV22OR9-2 grouped by GTF2IRD2B-low versus GTF2IRD2B-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2IRD2B→partner) and Y-score (partner→GTF2IRD2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TRBV22OR9-2 →	+0.850	+4.853	<.001	.004	3	2
SKCM	LINC00845 →	+0.060	+3.695	.003	.009	3	2
UCEC	CWC25 →	+0.408	+2.638	.004	.005	3	1
UCEC	ZNHIT3 →	+0.418	+3.245	.005	.008	3	1
UCEC	TAF9 →	+0.602	+3.087	<.001	<.001	3	1
UCEC	CCL4 →	+0.939	+4.191	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 663 associations by consensus.

TRBV22OR9-2 by GTF2IRD2B expression — LUSC

Explore this box plot interactively →