GTF2IRD2B

Across TCGA patient cohorts, GTF2IRD2B mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2IRD2B-associated genes across cancer lineages are eIF4E, ATM, and JNK_pT183_Y185. Each is linked with GTF2IRD2B in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2IRD2B-to-partner and partner-to-GTF2IRD2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by GTF2IRD2B-low versus GTF2IRD2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2IRD2B→partner) and Y-score (partner→GTF2IRD2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.191	+3.013	.028	.018	3	2
UCEC	ATM →	-0.651	-2.321	<.001	.006	3	2
UCEC	JNK_pT183_Y185 →	-0.166	-2.115	.017	.017	3	1
UCEC	Ku80 →	+0.201	+1.820	.039	.016	3	1
UCEC	MEK1 →	+0.456	+4.087	.002	<.001	3	1
UCEC	Notch1 →	+0.223	+2.598	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eIF4E by GTF2IRD2B expression — UCEC

Explore this box plot interactively →