Across TCGA patient cohorts, GTF2IRD2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2IRD2-associated genes across cancer lineages are 14-3-3_beta, TFRC, and Caspase-7-cleavedD198. Each is linked with GTF2IRD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2IRD2-to-partner and partner-to-GTF2IRD2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2IRD2→partner) and Y-score (partner→GTF2IRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.073	-1.847	.047	.049	3	2
UCEC	TFRC →	+0.588	+3.321	.002	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.534	+2.604	.014	.005	3	2
SKCM	Transglutaminase →	+0.219	+3.000	.031	.036	3	1
UCEC	EGFR →	-0.129	-2.973	.028	.035	3	1
UCEC	eIF4E →	+0.188	+1.847	.015	.008	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

GTF2IRD2 survival (RNA) · tumor vs normal (RNA) · all GTF2IRD2 data types