Across TCGA cell cohorts, GTF2IRD2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GTF2IRD2-associated genes across cancer lineages are OR6P1, SCGB1C1, and ADGRA1. Each is linked with GTF2IRD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2IRD2-to-partner and partner-to-GTF2IRD2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2IRD2→partner) and Y-score (partner→GTF2IRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR6P1 →	+0.016	+5.201	<.001	.006	3	1
BLOOD_Leukemia	SCGB1C1 →	+0.129	+5.539	<.001	.003	3	1
BLOOD_Leukemia	ADGRA1 →	+0.006	+5.201	<.001	.006	3	1
LARGE_INTESTINE	DMP1 →	+0.066	+4.137	<.001	.003	3	1
LARGE_INTESTINE	UGT2A1 →	+0.046	+3.777	.004	.007	3	1
LARGE_INTESTINE	C12orf40 →	+0.009	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

GTF2IRD2 survival (RNA) · tumor vs normal (RNA) · all GTF2IRD2 data types