GTF2IRD1P1

Across TCGA patient cohorts, GTF2IRD1P1 mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2IRD1P1-associated genes across cancer lineages are OR1L4, OR6K6, and RNU1-17P. Each is linked with GTF2IRD1P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2IRD1P1-to-partner and partner-to-GTF2IRD1P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L4 grouped by GTF2IRD1P1-low versus GTF2IRD1P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2IRD1P1→partner) and Y-score (partner→GTF2IRD1P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR1L4 →	+0.077	+2.755	.008	.009	3	1
UCEC	OR6K6 →	+0.090	+3.358	<.001	.006	3	1
UCEC	RNU1-17P →	+0.352	+3.613	<.001	.001	3	1
UCEC	SNORD114-18 →	+0.571	+3.299	<.001	.006	3	1
UCEC	RNU6-484P →	+0.874	+3.166	<.001	.001	3	1
UCEC	SNORD56B →	+0.579	+3.523	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

OR1L4 by GTF2IRD1P1 expression — UCEC

Explore this box plot interactively →