Across TCGA pan-cancer cohorts, GTF2IP8 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of GTF2IP8’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where GTF2IP8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GTF2IP8 is over-expressed in tumor.
THCA are the cancer types where GTF2IP8 tumor–normal differential expression is most reproducible.