Across TCGA pan-cancer cohorts, GTF2IP23 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GTF2IP23’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GTF2IP23 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GTF2IP23 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
KIRC, READ, and BLCA are the cancer types where GTF2IP23 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GTF2IP23 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.