GTF2IP22

Across TCGA pan-cancer cohorts, GTF2IP22 RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated GTF2IP22 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GTF2IP22 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GTF2IP22 expression acts as an unfavorable survival marker, although some lineages such as ESCA and SKCM show a favorable association.

HNSC, ESCA, and KIRC are the cancer types where GTF2IP22 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.276	0.648	.012	54	view →
ESCA	OS	Tertile	III,IV	1.000	0.372	.034	24	view →
KIRC	DFS	Tertile	All	0.260	0.796	.012	18	view →
PCPG	DFS	Tertile	All	0.088	0.846	.006	18	view →
SARC	OS	Tertile	All	0.302	0.746	.039	18	view →
COAD	DFS	Tertile	All	0.133	0.556	.047	9	view →
SKCM	OS	Tertile	All	0.931	0.776	.048	3	view →
STAD	DFS	Tertile	III,IV	0.796	0.540	.028	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

GTF2IP22–HNSC (OS)

Open the HNSC breakdown →