GTF2I

Across TCGA pan-cancer cohorts, GTF2I mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GTF2I data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GTF2I mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GTF2I expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LSCC, and HNSC are the cancer types where GTF2I mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	IV	0.943	0.231	.024	9	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.823	.022	8	view →
HNSC	DFS	Median	All	0.698	1.000	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GTF2I–PDAC (OS)

Open the PDAC breakdown →