GTF2I

Across TCGA pan-cancer cohorts, GTF2I mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of GTF2I’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GTF2I mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types GTF2I is over-expressed in tumor.

COAD, LUAD, and LSCC are the cancer types where GTF2I tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GTF2I mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.485	<.001	12	view →
LUAD	Male	II,III,IV	+0.367	<.001	9	view →
LSCC	Male	All	+0.618	<.001	8	view →
HNSC	Male	All	+0.169	.010	6	view →
CCRCC	Male	All	+0.134	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

GTF2I–COAD

Open the COAD breakdown →