GTF2I

Across TCGA patient cohorts, GTF2I mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. THYM shows the largest number of these associations.

The most reproducible GTF2I-associated genes across cancer lineages are JNK_pT183_Y185, EGFR_pY1068, and eIF4E. Each is linked with GTF2I in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2I-to-partner and partner-to-GTF2I results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by GTF2I-low versus GTF2I-high in THYM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2I→partner) and Y-score (partner→GTF2I) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	JNK_pT183_Y185 →	+0.108	+1.807	.002	.015	3	2
THYM	EGFR_pY1068 →	+0.156	+3.067	.008	.009	3	1
THYM	eIF4E →	-0.098	-3.408	.001	.002	3	1
THYM	FASN →	-0.292	-3.321	.003	.003	3	1
THYM	ACC1 →	-0.240	-3.169	.008	.008	3	1
THYM	Acetyl-a-Tubulin-Lys40 →	+0.319	+2.321	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

JNK_pT183_Y185 by GTF2I expression — THYM

Explore this box plot interactively →