GTF2I

Across TCGA cell cohorts, GTF2I RNA expression is significantly associated with the go_rna of many other GO terms, with 5,055 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GTF2I-associated GO terms across cancer lineages are Regulation of nucleotide-excision repair, Negative regulation of chromosome condensation, and Pre-mRNA catabolic process. Each is linked with GTF2I in more than 16 cancer types. Because this analysis shows association rather than direction, both GTF2I-to-partner and partner-to-GTF2I results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nucleotide-excision repair grouped by GTF2I-low versus GTF2I-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2I→partner) and Y-score (partner→GTF2I) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of nucleotide-excision repair →	+0.202	+1.136	<.001	<.001	3	17
SOFT_TISSUE	Negative regulation of chromosome condensation →	+0.159	+1.086	<.001	<.001	3	16
LARGE_INTESTINE	Pre-mRNA catabolic process →	+0.136	+0.783	<.001	<.001	3	16
SOFT_TISSUE	Positive regulation of double-strand break repair →	+0.069	+0.842	<.001	<.001	3	16
LUNG_SCLC	Nucleic acid transport →	+0.097	+0.954	<.001	.001	3	16
LUNG_SCLC	RNA transport →	+0.097	+0.954	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,055 associations by consensus.

Regulation of nucleotide-excision repair by GTF2I expression — STOMACH

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