GTF2I

Across TCGA cell cohorts, GTF2I mutation is significantly associated with the RNA expression of many other genes, with 471 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GTF2I-associated genes across cancer lineages are ACER1, PROP1, and FCN2. Each is linked with GTF2I in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2I-to-partner and partner-to-GTF2I results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by GTF2I-low versus GTF2I-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2I→partner) and Y-score (partner→GTF2I) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.074	+2.086	<.001	.009	3	2
LUNG_NSCLC_LUAD	PROP1 →	+0.035	+5.149	<.001	<.001	3	2
URINARY_TRACT	FCN2 →	+0.025	+4.087	<.001	.009	3	1
URINARY_TRACT	SERPINA2 →	+0.197	+4.217	.006	.005	3	1
LUNG_SCLC	CLEC9A →	+0.042	+4.523	<.001	.003	3	1
LARGE_INTESTINE	EIF3L →	+0.665	+3.389	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 471 associations by consensus.

ACER1 by GTF2I expression — LARGE_INTESTINE

Explore this box plot interactively →