Across TCGA patient cohorts, GTF2H4 mutation is significantly associated with the RNA expression of many other genes, with 980 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2H4-associated genes across cancer lineages are RNA5SP325, MIR8070, and SPECC1P2. Each is linked with GTF2H4 in more than 2 cancer types. Because this analysis shows association rather than direction, both GTF2H4-to-partner and partner-to-GTF2H4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2H4→partner) and Y-score (partner→GTF2H4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP325 →	+0.256	+3.623	<.001	.006	3	3
UCEC	MIR8070 →	+0.432	+2.354	.005	.002	3	2
LUSC	SPECC1P2 →	+0.251	+4.475	.008	.005	3	2
LUSC	H3Y2 →	+0.603	+4.919	<.001	.002	3	2
UCEC	RNU6-1180P →	+0.182	+3.761	<.001	.001	3	2
UCEC	RNU1-57P →	+0.219	+4.354	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 980 associations by consensus.

Exploration

GTF2H4 survival (RNA) · tumor vs normal (RNA) · all GTF2H4 data types